Lornoxicam tablets were prepared by conventional wet granulation method using various binding agents. Lornoxicam, a widely prescribed non steroidal anti-inflammatory drug with analgesic properties, belonging to the oxicam class. The objective of the present work was to study the effect of various binding agents on qualities and dissolution rate of lornoxicam tablets. Compressed tablets each containing 8 mg of lornoxicam were prepared using various binders namely acacia, tragacanth, gelatin, xantham gum, HPMC K4M, PVP K30, PVA and MCC. The effects of binding agents on the physical characteristics of lornoxicam granules were studied. The granules were evaluated for angle of repose, bulk density, compressibility index and the tablets were evaluated for content of active ingredient, hardness, friability, disintegration time, dissolution rate. The binder used has significant influence on the tablet and rate of lornoxicam release from the tablets.
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